If you are using Outlook.exe on a Windows XP Machine and the exe file is set to run in compatibility mode with any previous operating system then you might get an error message stating “Unable to open the Outlook window”, “No profile has been created”, or “The list of Profiles cannot be loaded”. This is because the location of the Outlook’s Profile information in the registry differs on a Windows XP-based computer than that of a computer running on Windows 98 or on Windows ME edition.

How to fix this issue

This issue can be fixed by three methods – 

Method One (Changing the compatibility mode)

  1. Browse to the location of Outlook.exe.Location may vary depending upon the version of Outlook installed:Microsoft Outlook 2000 – C:\Program Files\Microsoft Office\Office 9Microsoft Outlook 2002 – C:\Program Files\Microsoft Office\Office 10Microsoft Office Outlook 2003 – C:\Program Files\Microsoft Office\Office 11Microsoft Office Outlook 2007 – C:\Program Files\Microsoft Office\Office12Microsoft Office Outlook 2010 – C:\Program Files\Microsoft Office\Office14
  2. Right click on Outlook.Exe and select Properties
  3. Click the Compatibility Tab
  4. Clear the Checkbox “Run this program in Compatibility Mode”
  5. Click OK
  6. Try Restarting Outlook and this would have fixed the problem.

Method Two (Registry Modification)

(Working with Windows registry is really dangerous for your system. So don’t ever work with registry unless taking a backup of your system or creating a restore point.)

  1. Click Start -> Run
  2. In the Run box type Regedit (Regedit is a command used for editing the registry)
  3. Locate the following Registry Key:HKEY_CURRENT_USER\Software\Microsoft\Windows NT\CurrentVersion\Windows Messaging Subsystem\Profiles
  4. Delete the Profiles key by Right clicking on it and selecting delete.
  5. Restart the computer for changes to take effect.

Taking backup of Windows Registry

  1. Click Start->Run
  2. In the Run box type Regedit
  3. In the Regedit window click on File and select Export
  4. In the Export box give a name to your backup file
  5. Select what you want to export from the two Radio buttons given at the bottom of Export Windowa. All – Will export the entire registry to the backup file.b. Selected Branch – Will export only the branch which is highlighted.
  6. Click Save.
  7. To restore Registry you just need to double click on the Backup file. It will ask if you wish to write the information to the Registry or Not? Select yes.

If you are not comfortable making these changes then please do not make changes in the Registry

Method Three (Using Microsoft’s Fixit utility)

  1. Browse to the following link:http://go.microsoft.com/?linkid=9661301
  2. Download the .msi file and execute it on the computer where you are facing the Outlook Issue.
  3. Restart the computer

This Article applies to Microsoft Office Outlook 2007, Microsoft Office Outlook 2007 with Business Contact Manager, Microsoft Office Outlook 2003, Microsoft Office Outlook 2003 with Business Contact Manager, Microsoft Outlook 2002 Standard Edition, and Microsoft Outlook 2000.